生醫組

基本資料表

謝明麗
886-4-23590121 ext 32443 (office), 32444 (lab)
mhsieh@go.thu.edu.tw
886-4-23590296
謝明麗

教師

專任教師生醫組
終身特聘教授
普通生物學、分子生物學、遺傳工程
神經退化性疾病、分子醫學、轉錄調控機制
年度論文名稱
2019Protective roles of carbonic anhydrase 8 in Machado-Joseph disease.
2018Promoter analysis and transcriptional regulation of human carbonic anhydrase VIII gene in a MERRF disease cell model.
2017Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3.
2017Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
2016Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function.
2016Endothelin-1 promotes epithelial–mesenchymal transition in human chondrosarcoma cells by repressing miR-300.
2016Novel findings of secreted cyclophilin A in diabetic nephropathy and its association with renal protection of dipeptidyl peptidase 4 inhibitor.
2015Urinary cyclophilin A as a new marker for diabetic nephropathy: A Cross-Sectional Analysis of diabetes mellitus.
2015Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells.
2014Roles of carbonic anhydrase 8 in neuronal cells and zebrafish.
2013Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery.
2013Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation.
2012Secreted Cyclophilin A Induction during Embryo Implantation in a Model of Human Trophoblast-Endometrial Epithelium Interaction.
2012The Protective Roles of Phosphorylated Heat Shock Protein 27 in Human Cells Harboring MERRF A8344G Mitochondrial DNA Mutation.
2012Altered expression of carbonic anhydrase-related protein XI in neuronal cells expressing mutant ataxin-3.
2011The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein.
2011Decreased Heat Shock Protein 27 Expression and Altered Autophagy in Human Cells harboring A8344G Mitochondrial DNA Mutation.
2011A high dynamic range vector quantisation for compressing 2DGE images of different exposures.
2009Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
2009Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
2007AH23848 accelerates inducible nitric oxide synthase degradation through attenuation of cAMP signaling in glomerular mesangial cells.
2007The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability.   
2007Characterization of protein arginine methyltransferases in porcine brain.
2007Asian origin for the worldwide-spread mutational event in Machado-Joseph disease.
2006Content-based progressive transmission of 2-DGE images.
2005Dynamic expression of Hsp27 in the presence of mutant ataxin-3.
2005Decreased expression of Hsp27 and Hsp70 in transformed lymphoblastoid cells from patients with spinocerebellar ataxia type 7.
2004Clinical and Molecular Events in Patients with Machado-Joseph Disease under Lamotrigine Therapy.
2004Low RET mutation frequency and polymorphism analysis of the RET and EDNRB genes in patients with Hirschsprung disease in Taiwan.
2004Machado-Joseph Shoe.
2004HSP27 and cell death in Spinocerebellar Ataxia Type 3.
2004Effects of adenosine dialdehyde treatment on in vitro and in vivo stable protein methylation in HeLa cells.
2004Full-Length Expanded Ataxin-3 Enhances Mitochondrial Mediated Cell Death and Decreases Bcl-2 Expression in Human Neuroblastoma Cells.
2003Analysis of trinucleotide repeats in different SCA loci in spinocerebellar ataxia patients and in normal population of Taiwan.
2003Down-Regulation of Heat Shock Protein 27 in Neuronal Cells and Non-neuronal cells Expressing Mutant Ataxin-3.
2002Prenatal diagnosis of Machado-Joseph disease/ Spinocerebellar Ataxia Type 3 in Taiwan: early detection of expanded ataxin-3.
2002Arginine methylation of recombinant murine fibrillarin by protein arginine methyltransferase.
2002Proteomic Analysis of stable Protein Methylation in Lymphoblastoid Cells.
2000Ancestral origins of the Machado-Joseph disease mutation: a worldwide haplotype study.
2000Molecular, Clinical Studies and Review in Spinocerebellar Ataxia Type 2.
2000Protein N-Arginine methylation in subcellular fractions of lymphoblastoid Cells.
2000Identification of the spinocerebellar ataxia type 7 mutation in Taiwan: application of PCR-based Southern blot.
2000Distribution of CAG repeat size in the Dentatorubal and Pallidoluysian Atrophy (DRPLA) gene in a normal population in Taiwan.
1999The hydrophobic heptad repeat in Region III of Escherichia coli transcription factor sigma 54 is essential for core RNA polymerase binding.
1999Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin.
1999Identification of five Spinocerebellar Ataxia type 2 pedigrees in patients with autosomal dominant cerebellar ataxia in Taiwan.
1999A non-radioactive PCR method for diagnosis of Machado-Joseph Disease.
1998Amplification of GAA/TTC triplet repeat in vitro: preferential expansion of (TTC)n strand.
1998Protein-N-arginine methylation in adenosine dialdehyde treated lymphoblastoid cells.
1997The CAG repeats number of spinocerebellar ataxia type 1 gene in normal Taiwanese and in patients with dominant inherited ataxia.
1997Growth-phase-dependent transcriptional regulation of the pcm and surE gene required for stationary-phase survival of Escherichia coli.
1997studies of the CAG repeat in the Machado-Joseph disease gene in Taiwan.
1995Converting Escherichia coli RNA polymerase into an enhancer-responsive enzyme: role of an NH2-terminal leucine patch in sigma 54.
1994Functional roles of the glutamines within the glutamine-rich region of transcription factor sigma 54.
1993Analysis of the N-terminal leucine heptad and hexad repeats of sigma 54.
1993RNA polymerase binding using a strong acidic hydrophobic-repeat region of sigma 54.
1988New Coupling recation of 0-phenylenediamine catalyzed by Mn(II) ion.
年度計畫名稱參與人計畫期間補助/委託或合作機構
2017新穎的葡萄糖代謝機制在大腸癌上的治療策略－新穎的葡萄糖代謝機制 (3/3)謝明麗、龍鳳娣、趙偉廷、蔡玉真、盧錫祺、謝長奇、吳旻寰2017-08~2018-07科技部 (MOST)
2016碳酸酐酶第八型在神經退化性疾病的保護功能與葡萄糖代謝機制作用：利用細胞和小鼠的研究謝明麗2016-08~2019-07科技部
2016新穎的葡萄糖代謝機制在大腸癌上的治療策略－新穎的葡萄糖代謝機制 (2/3) 謝明麗、龍鳳娣、趙偉廷、蔡玉真、盧錫祺、謝長奇、吳旻寰2016-08~2017-09科技部 (MOST)
2015碳酸酐酶第八型在人類神經肌肉疾病的轉錄調控和保護功能機制分析：利用細胞和小鼠的研究謝明麗2015-08~2016-07科技部 (MOST)
2015新穎的葡萄糖代謝機制在大腸癌上的治療策略－新穎的葡萄糖代謝機制在大腸癌上的治療策略(1/3)謝明麗、龍鳳娣、趙偉廷、蔡玉真、盧錫祺、謝長奇、吳旻寰2015-08~0000-00科技部 (MOST)
2014碳酸酐脢第八型在運動協調及癌變過程的角色研究謝明麗2014-08~2015-07科技部 (MOST)
2013野生型和突變型碳酸酐脢第八型在神經肌肉退化性疾病的分子與功能研究 : 使用神經細胞與動物模式的研究謝明麗2013-08~2014-07國科會 (NSC)
2012人類碳酸酐酶相關蛋白在遺傳性神經肌肉疾病中的分子與功能分析:以細胞與斑馬魚模式之研究謝明麗2012-08~2013-07國科會 (NSC)
2011以細胞與斑馬魚模式探討CA8 在遺傳性共濟失調症中的角色謝明麗2011-08~2012-07
2008以細胞與果蠅模式研究熱休克蛋白27在粒線體疾病中的角色謝明麗, 陳靜怡, 劉書瑜2008-08~2011-07國科會
2007Cyclophilin A 及氧化LDL在人類血管疾病之應用謝明麗2008-01~2008-12
2007小腦脊髓運動失調第三型/馬卡多-喬瑟夫疾病分子機制及治療性化合物測試謝明麗, 張偉修, 許季甫, 楊吉盛, 陳姿融2007-08~2008-08國科會
年度獎項名稱頒獎單位
2007東海大學頂尖研究獎東海大學
學校名稱國別系所學位起迄年月
加州大學洛杉磯分校美國化學與生化學系博士1988-09~1993-09
臺灣大學化學系學士1983-09~1987-06
服務機關名稱單位職務期間
東海大學生命科學系教授2015-08~0000-00
東海大學生命科學系教授2012-08~0000-00
東海大學生命科學系教授2003-08~0000-00
中山醫學大學生命科學系教授2002-08~2003-07
中山醫學大學生命科學系教授2001-08~2002-07
Fox Chase 癌症中心2001-02~2001-08
中山醫學大學生命科學系教授2000-01~2001-07