生醫組

基本資料表

劉薏雯
886-4-23590121 ext 32432(office)、32433(lab)
dlslys@thu.edu.tw
886-4-23590296
http://thdlsywliu.wixsite.com/yiwenliulab
劉薏雯

教師

專任教師生醫組
教授
遺傳學、發育生物學、分子細胞生物學、分子生物學、醫藥生物化學綜論
斑馬魚模式的生物醫學；腎臟的發育與疾病；分子內分泌學；罕見疾病研究
年度論文名稱
2023The anti-platelet drug cilostazol enhances heart rate and interrenal steroidogenesis and exerts a scant effect on innate immune responses in zebrafish
2020Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish
2019Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged–Notch signaling in fin and limb development.
2017Aberrant global and Jagged-mediated Notch signaling disrupts segregation between wt1-expressing and steroidogenic tissues in zebrafish
2017Chlorella diet alters mitochondrial cardiolipin contents differentially in organs of Danio rerio analyzed by a lipidomics approach
2016The endoderm indirectly influences morphogenetic movements of the zebrafish head kidney through the posterior cardinal vein and VegfC
2016Visualizing the interrenal steroidogenic tissue and its vascular microenvironment in zebrafish
2014The hemodynamically-regulated vascular microenvironment promotes migration of the steroidogenic tissue during its interaction with chromaffin cells in the zebrafish embryo
2013Fibronectin mediates correct positioning of the interrenal organ in zebrafish
2013Roles of carbonic anhydrase 8 in neuronal cells and zebrafish
2012Development and fibronectin signaling requirements of the zebrafish interrenal vessel.
2010Arterial and venous vessels are required for modulating developmental relocalization and laterality of the interrenal tissue in zebrafish.
2007Characterization of porcine arterial endothelial cells cultured on amniotic membrane, a potential matrix for vascular tissue engineering.
2006Interrenal organogenesis in the zebrafish model.
2006Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development.
2003Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.
2003Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ.
年度論文名稱
2024Hsien-Fu Chiu, Guan-Yi Tsai, Yu-Shan Huang, Wei-Leng Chen, Chen-Wei-Su, Yi-Hua Tang and Yi-Wen Liu,Mutation of sphingosine-1-phosphate receptor 2 promotes kidney cystogenesis: mechanistic analysis,2024 Taiwan Zebrafish Symposium,2024-12-2024-12
2023Chih-Wei Chou, Jin Tian, Jamie Lin, Hsin-Yu Hou, Sheng-Hua Li, Yun-Jin Jiang and Yi-Wen Liu,Using the zebrafish model to study mechanisms underlying parallel development of kidney and interrenal tissues: implications in human rare diseases,Second International Symposium of Chinese Comparative Endocrinologists,2023-10-2025-10
2022Wei-Chun Chang, Mei-Jen Chen, Yu-Fu Chen, Chih-Wei Chou, Yung-Jen Chuang and Yi-Wen Liu,The anti-platelet drug cilostazol enhances heart rate and interrenal steroidogenesis without affecting innate immune responses in zebrafish,12th European Zebrafish Meeting,2023-07-2023-07
2020Hsien-Fu Chiu, Mei-Jen Chen, Wei-Leng Chen, Yi-Wen Liu,Mutation of sphingosine-1-phosphate receptor 2 promotes kidney cystogenesis: mechanistic analysis,2020 Taiwan Zebrafish Symposium,2020-11-2020-11
2019Yi-Wen Liu,Deciphering the molecular and cellular mechanisms that regulate organogenesis of the interrenal gland,Neuropeptides and Hormone in Marine Organisms,2019-07
2018Wei-Chun Chang, Yu-Fu Chen, Yi-Wen Liu,Effects of Cilostazol for brain angiogenesis and interrenal steroidogenesis in the zebrafish,2018 Taiwan Zebrafish Symposium,2018-11
2017Chih-Wei Chou, Jamie Lin, Yun-Jin Jiang and Yi-Wen Liu,Exploring the role of Jagged-Notch signaling for organ size control and steroidogenesis of the interrenal gland,Gordon Research Conference on Notch Signaling in Development, Regeneration and Disease,2018-07
2016Chih-Wei Chou, Jamie Lin, Yun-Jin Jiang and Yi-Wen Liu,Jagged molecules are required for promoting parallel development of the pronephros and the interrenal tissue,10th European Zebrafish Meeting,2017-07
2016Chih-Wei Chou, Hsin-Yu Hou, Jamie Lin, Jing Tian and Yi-Wen Liu,Studying the role of low density lipoprotein receptor-related protein 4 (Lrp4) for the zebrafish head kidney development,2016 Taiwan Zebrafish Symposium,2016-12
2016Chih-Wei Chou, Hsiao-Chu Hsu, May-su You, Jamie Lin and Yi-Wen Liu,The endoderm indirectly influences morphogenetic movements of the head kidney through the posterior cardinal vein and VegfC,7th Asia Oceania Zebrafish Meeting,2016-10
2016Hsin-Yu Hou, Chih-Wei Chou, Pan Zhang, Jamie Lin, Kuan-Chieh Wang, Jing Tian and Yi-Wen Liu,The role of low density lipoprotein receptor-related protein 4 for the fin development in zebrafish,2016 Taiwan Zebrafish Symposium,2016-12
2015Yi-Wen Liu, Chih-Wei Chou, Hsiao-Chu Hsu and Maysu You,Genetic epistatis between sox32 and cloche reveals a role of venous vasculature for the patterning of head kidney in zebrafish,Asia-Pacific Developmental Biology Conference 2015,2015-09
2015Chih-Wei Chou, Jamie Lin, Yun-Jin Jiang, Yi-Wen Liu,Studying the regulatory pathway for the specification of the head kidney in zebrafish,2015 Taiwan Zebrafish Symposium,2015-12
2015Chih-Wei Chou, Jamie Lin, Yun-Jin Jiang and Yi-Wen Liu,The role of Jagged-Notch signaling for the development of ff1b/nr5a1a-expressing interrenal tissue in the zebrafish,8th International Symposium on Fish Endocrinology (8ISFE),2016-06
2015Hsin-Yu Hou, Pan Zhang, Chi-Wei Chou, Jamie Lin, Kuan-Chieh Wang, Jing Tian and Yi-Wen Liu,The role of low density lipoprotein receptor-related protein 4 for the fin and kidney development in zebrafish,2015 Taiwan Zebrafish Symposium,2015-12
年度計畫名稱參與人計畫期間補助/委託或合作機構
2024運用斑馬魚模式研究Sphk/S1P/Spns2/S1pr2 路徑軸調控腎元型態生成的分子細胞機制：與囊性腎病變之關聯性2024-08~2024-07國科會
2023利用斑馬魚模式研究Spns2-S1P-S1pr2訊號軸在腎臟發育及腎囊腫形成中的角色2023-08~2024-10國科會
2023Screening for a transgenic driver line specifying kidney tubular epithelium for the study of renal dKoichi Kawagami2023-04~2024-03National Institute of Genetics, Japan
2022利用斑馬魚模式探討S1P-S1pr2訊號軸在腎囊腫形成及腎纖毛病變機制中的角色2022-08~2023-10國科會
2020利用斑馬魚模式探討Lrp4在腎臟發育及再生過程中如何調節足細胞的分化、微環境及功能2020-08~2022-07科技部
2017利用斑馬魚模式研究Lrp4在腎臟發育、損傷及再生過程中的角色2017-08~2020-10科技部
2016探討Lrp4及Notch訊號傳遞如何調控斑馬魚腎臟、腎間腺與魚鳍的發育2016-08~2017-07科技部
2013探討血流及血管微環境如何調控斑馬魚腎間腺之器官形成與血管新生2013-08~2016-07科技部
2012探討血管微環境和促血管新生因子在斑馬魚腎間腺器官發育中所扮演的角色2012-08~2013-07科技部
2011利用斑馬魚模型探討Notch訊號傳遞途徑如何調控腎臟及腎間腺之平行發育2011-08~2012-07國科會
2010探討Notch訊號傳遞途徑在斑馬魚腎間腺器官發生中所扮演之角色2010-08~2011-07國科會
2010洞察自然：從分子至演化層級探討離子壓力、視覺與聽覺訊號作用機制之整合性跨領域研究--洞察自然：從分子至演化層級探討離子壓力、視覺與聽覺訊號作用機制之整合性跨領域研究2010-08~2011-07國科會
2007內皮細胞訊號調控斑馬魚腎間腺早期型態發生之探討2007-08~2010-07國科會
2006Ftz-F1在斑馬魚器官發生過程中如何調控prox1之基因表達2006-08~2007-07國科會
2003Prox1對Ff1b於班馬魚adrenal/interrenal 發育過程中之輔助調控2003-08~2006-07
學校名稱國別系所學位起迄年月
臺灣清華大學中華民國生命科學所博士1988-09~1994-10
服務機關名稱單位職務期間
東海大學生命科學系系主任2020-02~2023-01
東海大學博雅書院知識與學習委員會召集人2018-09~2020-01
東海大學生命科學系教授2015-02~
東海大學博雅書院導師2014-09~
東海大學生命科學系副教授2007-08~2015-01
東海大學生命科學系助理教授2003-09~2007-07
中山醫學大學生命科學系助理教授2003-02~2003-08
新加坡大學生物科學系分子遺傳學實驗室研究員2002-08~2003-02
新加坡國立分子農學院研究員1996-02~2002-06
新竹健亞股份有限公司研究員1994-10~1996-02